Wallenberg - NTU Postdoctoral Fellow

1 month ago


Singapore NTU (Nanyang Technology University- Main Office-HR) Full time
The Wallenberg-NTU Postdoctoral Fellowship is to bring outstanding young researchers, who have graduated from a Swedish university, to NTU for two years of postdoctoral research and studies. The Postdoctoral Fellows are given the opportunity to participate in a broad range of interdisciplinary activities and programs that characterize NTU's approach to research and education.

Key Responsibilities:
  • Conduct molecular dynamics (MD) simulations to investigate the conformational changes and dynamics of specific proteins.
  • Utilize machine learning-driven structure prediction to model and validate potential protein conformations.
  • Analyze free energy landscapes to understand the stability and equilibrium of protein conformations during activation process.
  • Apply structure-based virtual screening (SBVS) using deep learning frameworks to identify and evaluate new small-molecule targeting specific drug targets.
  • Conduct molecular docking and free energy calculations to predict binding affinity and efficacy of potential binders.
  • Collaborate with experimental biologists to validate computational predictions through site-directed mutagenesis and other biochemical assays.
  • Work with medicinal chemists to optimize lead compounds for better affinity, potency, and drug-like properties.


Job Requirements:
  • Ph.D. degree related to Computational biophysics, Molecular Biology, Bioinformatics or Computational Chemistry.
  • Strong computational skills, including molecular dynamics (MD) simulations, machine learning-driven structure prediction, and enhanced sampling techniques.
  • Skilled in using computational software such as GROMACS and AMBER simulations; proficiency in programming languages like Python for data analysis and machine learning
  • Good knowledge in computational biophysics, molecular biology, biochemistry, and drug discovery.
  • Demonstrated ability to work collaboratively with structural biologists, medicinal chemists, and experimental biologists
  • Excellent written and oral communication skills for documenting research findings, preparing reports, and presenting results to diverse audiences.


We regret that only shortlisted candidates will be notified.

Hiring Institution: NTU

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