Senior Scientist
1 week ago
Chugai Pharmabody Research Pte. Ltd. ("CPR") was established in Singapore as a wholly-owned subsidiary of Chugai Pharmaceutical Co., Ltd (Chugai), a member of Roche group, in January 2012 and started operations on July 2, 2012. Located at Biopolis in Singapore, it aims to generate new antibody drugs based on Chugai's proprietary antibody engineering technologies, such as recycling antibody, sweeping antibody, bispecific antibody, various Fc engineered antibodies, and other new antibody engineering technologies that are under development.
Position Summary– Senior Scientist in Pharmacokinetic unit
As a Senior Scientist in CPR, you will leverage your passion and creativity to lead an innovative antibody drug project through a characterization of drug candidates, collaborating with other multi-disciplinary teams to achieve a milestone of a project. The candidate will play a key role to drive our innovative drug discovery project and technology development by determining mechanism of biologics through characterizing its ADME and Pharmacokinetic/Pharmacodynamic (PK/PD) properties with in vitro and in vivo analysis. During the process, the candidate will have an opportunity to describe the mechanism with modeling & simulation and to translate preclinical PK/PD results to human.
Job Requirements
The applicant should be highly skilled in Immunoassay development and analysis of biological samples:
· Immunoassay development: ELISA and related technology platforms such as Gyros, Simoa, Luminex and MesoScale Discovery etc.
· Analysis of biological samples: Plasma, Serum, Biological fluid, Tissue homogenate (preclinical/clinical)
It would be an added advantage if the applicant is also skilled in the following areas:
· Pharmacokinetics analysis and Modeling & Simulation
· Molecule labeling and biodistribution study
· Cell-based assay development
· Molecular biology techniques such as gene transfection, flow cytometry analysis, immunoprecipitation, western blot etc.
The applicant must have completed and be awarded with a relevant Ph.D. degreein Pharmaceutical science/Biomedical Science/Biochemistry/Chemical Biology/Biotechnology/Information sciencewith 1-2 years of working experience in a related field. In addition, the successful candidates must be able to demonstrate their molecular and cellular biology expertise as evidenced by projects, presentations, or peer-reviewed scientific publications.
Scientists with strong passion in medical science for creating and delivering innovative drugs to society which leads to saving patients suffering from unmet medical needs are highly desired. Familiarity or having prior work experience in antibody drug discovery work will be a plus, although not absolutely necessary. You should also possess good command of spoken and written English, excellent organizational and communication skills, team player mindset, as well as the ability to perform multi-task.
For more information regarding our Company, you may refer to our website at:
http://chugai-pharmabody.com/
We regret that only short-listed candidates will be notified
Tell employers what skills you havein Vivo
Written English
Modeling
Technology Development
Transfection
Assay Development
ELISA
Biology
Characterization
Flow Cytometry
Drug Discovery
Molecular Biology
Publications
Antibodies
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