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Quality Control Lead

4 months ago

Singapore CELLVEC PTE. LTD. Full time
Responsible for the operational aspects of all analytical testing within the QC Laboratory.

  • Lead, coach and develop QC personnel (analysts and scientists) to ensuring that analytical testing and data review is performed in a reliable and timely manner to support production operations with adherence to Standard Operating Procedures (SOP).
  • Ensure that the quality systems and practices in the laboratory comply with Good Laboratory Practices (GLP), Good Documentation Practices (GDP), current Good Manufacturing Practices (cGMP) and Quality Management Standards (QMS).
  • Develop, optimize, implement analytical methods and working procedures for characterization, release, and stability testing of viral vector gene therapy products.
  • Develop the organisation's quality testing policy in alignment with regulatory standards.
  • Lead and perform lab method validation, transfers of analytical methods from other collaborators/clients, protocol harmonization and optimization from R&D to Production.
  • Lead development and qualification of new and/or improved assays and characterization of viral vector products using molecular, biophysical, and other analytical assays.
  • Conduct, review or approve laboratory investigations and ensure all follow up actions are completed. Make decisions based on scientific and logical reasoning.
  • Compile data, generate reports and perform computations using data analysis software, spreadsheets, graphing, and curve fitting software.
  • Align with MSAT, Quality and Production teams on phase appropriate analytical methods and strategies for inprocess and QC release testing.
  • Collaborate with team members to identify and evaluate assay improvements with the goal of optimizing the current rAAV production process.
  • Train fellow colleagues on written procedures pertaining to equipment operation, test methods and general laboratory operations.
  • Draft and edit lab protocols, standard operating procedures, sampling plans, technical documents, and release testing records for regulatory or tech transfer purposes.
  • Ensure real time documentation, maintain data integrity and appropriate traceability as per quality system.